Ngā mate neurodegenerativeKo ngā NDD (Ngā NDD) e tohuhia ana e te ngaronga haere tonu, te ngaronga tonu rānei o ngā taupori io ngoikore motuhake i roto i te roro, i te taurakira rānei. Ka taea te whakarōpū i ngā NDD i runga i ngā paearu maha, tae atu ki te tohatoha anatomical o te neurodegeneration (pēnei i ngā mate extrapyramidal, te degeneration frontotemporal, te spinocerebellar ataxias rānei), ngā rerekētanga ngota tuatahi (pēnei i te amyloid-β, prions, tau, α-synuclein rānei), ngā āhuatanga haumanu nui rānei (pēnei i te mate a Parkinson, te amyotrophic lateral sclerosis, me te dementia). Ahakoa ēnei rerekētanga i roto i te whakarōpūtanga me te whakaaturanga tohu, he rite tonu ngā tukanga matua o ngā mate pēnei i te Mate a Parkinson (PD), te Amyotrophic Lateral Sclerosis (ALS), me te Mate a Alzheimer (AD) e arahi ana ki te ngoikore o te io me te mate pūtau i te mutunga.
E ai ki te whakatau tata a te World Health Organization, i te mea e miriona ngā tāngata o te ao e pāngia ana e ngā NDD, ka noho ēnei mate hei tuarua o ngā tino take o te mate i ngā whenua whakawhanake. Ahakoa he maha ngā maimoatanga e wātea ana hei whakamamae me te whakahaere i ngā tohu e pā ana ki ngā mate motuhake, kāore tonu i te tino kitea ngā tikanga whai hua hei whakaroa, hei whakaora rānei i te whanaketanga o ēnei āhuatanga. E whakaatu ana ngā rangahau hou i te nekehanga o ngā tauira maimoatanga mai i te whakahaere tohu noa ki te whakamahi i ngā tikanga tiaki pūtau hei ārai i te kino haere. E whakaatu ana ngā taunakitanga whānui he mea nui te ahotea waikura me te mumura ki te neurodegeneration, e whakanoho ana i ēnei tikanga hei whāinga nui mō te tiaki pūtau. I ngā tau tata nei, kua hurahia e ngā rangahau taketake me ngā rangahau haumanu te kaha o te Hyperbaric Oxygen Therapy (HBOT) ki te rongoā i ngā mate neurodegenerative.
Te Mārama ki te Whakaora Hāora Hyperbaric (HBOT)
Ko te HBOT te tikanga he whakanui ake i te pēhanga ki runga ake i te 1 hauhautanga tino (ATA) — te pēhanga i te taumata moana — mō te roanga o te 90-120 meneti, he maha ngā wā e hiahiatia ana he wā mahi i runga i te āhua o te mate e rongoatia ana. Mā te pēhanga hau kua whakanuia ka pai ake te tuku hāora ki ngā pūtau, ka whakaoho i te tipu o ngā pūtau take me te whakarei ake i ngā tukanga whakaora e whakahaerehia ana e ētahi āhuatanga tipu.
I te tīmatanga, i ahu mai te whakamahinga o te HBOT i te ture Boyle-Marriott, e whakaatu ana i te whakaiti i ngā mirumiru hau e whakawhirinaki ana ki te pēhanga, me ngā painga o ngā taumata hāora teitei i roto i ngā kiko. He maha ngā mate e mōhiotia ana ka whai hua mai i te āhua hyperoxic i puta mai i te HBOT, tae atu ki ngā kiko necrotic, ngā whara radiation, te whara, ngā wera, te mate compartment, me te gangrene hau, me ētahi atu kua whakarārangihia e te Undersea and Hyperbaric Medical Society. He mea nui, kua whakaatuhia hoki e te HBOT te whai huatanga hei maimoatanga tāpiri i roto i ngā tauira mate mumura, mate pāwera rānei, pērā i te colitis me te sepsis. I runga i ana tikanga anti-inflammatory me te oxidative, he nui te kaha o te HBOT hei huarahi rongoā mō ngā mate neurodegenerative.
Ngā Rangahau ā-Mua mō te Whakaora Hāora Hyperbaric i roto i ngā Mate Neurodegenerative: Ngā Tirohanga mai i te Tauira Kiore 3×Tg
Ko tētahi o ngā rangahau rongonuii arotahi ki te tauira kiore 3×Tg o te mate a Alzheimer (AD), i whakaatu i te pūmanawa rongoā o te HBOT ki te whakapai ake i ngā ngoikoretanga hinengaro. I uru atu ki te rangahau ngā kiore tāne 3×Tg 17-marama te pakeke, ki te whakataurite ki ngā kiore tāne C57BL/6 14-marama te pakeke hei mana whakahaere. I whakaatuhia e te rangahau kāore i te whakapai ake noa te HBOT i te mahi hinengaro engari i whakaiti nui hoki i te mumura, te kawenga papa, me te phosphorylation Tau—he tukanga nui e pā ana ki te mate AD.
Ko ngā pānga tiaki o te HBOT i kīia he whakahekenga o te mumura roro. I kitea tēnei mā te whakahekenga o te tipu o te microglial, te astrogliosis, me te whakaputanga o ngā cytokine pro-inflammatory. E whakanui ana ēnei kitenga i te mahi takirua a te HBOT ki te whakarei ake i te mahi hinengaro, me te whakaiti anō hoki i ngā tukanga mumura roro e pā ana ki te mate a Alzheimer.
I whakamahia e tētahi atu tauira haumanu-mua ngā kiore 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) hei aromatawai i ngā tikanga tiaki o te HBOT ki te mahi neuronal me ngā āheinga nekeneke. I whakaatuhia e ngā hua i whai wāhi te HBOT ki te whakarei ake i te ngohe nekeneke me te kaha hopu i roto i ēnei kiore, e hono ana ki te pikinga o te tohu biogenesis mitochondrial, inā koa mā te whakahohenga o SIRT-1, PGC-1α, me TFAM. E whakaatu ana tēnei i te tūranga nui o te mahi mitochondrial i roto i ngā pānga tiaki neuro o te HBOT.
Ngā Tikanga o te HBOT i roto i ngā Mate Neurodegenerative
Ko te kaupapa matua o te whakamahi i te HBOT mō ngā NDD kei roto i te whanaungatanga i waenga i te iti o te tuku hāora me te ngoikore ki ngā huringa neurodegenerative. He mahi matua tā te Hypoxia-inducible factor-1 (HIF-1) hei factor transcription e āhei ai te urutau pūtau ki te iti o te haunga hāora, ā, kua whai pānga ki ngā momo NDD tae atu ki te AD, PD, Huntington's Disease, me te ALS, e tohu ana he ūnga rongoā nui.
Nā te mea he take nui te koroheketanga mō ngā mate pūnaha io maha, he mea nui kia tirohia te pānga o te HBOT ki te koiora io o te koroheketanga. Kua whakaatuhia e ngā rangahau ka taea e te HBOT te whakapai ake i ngā ngoikoretanga hinengaro e pā ana ki te koroheketanga i roto i ngā kaumātua hauora.I tua atu, i whakaatuhia e ngā tūroro kaumātua he nui te ngoikore o te mahara he whakapainga hinengaro me te pikinga o te rere o te toto roro whai muri i te pānga ki te HBOT.
1. Te Pānga o te HBOT ki te Mumura me te Taumahatanga Waikura
Kua whakaatuhia e te HBOT te kaha ki te whakaiti i te mumura o te roro i roto i ngā tūroro he nui te ngoikore o te roro. Kei a ia te kaha ki te whakaheke i te kaha o ngā cytokine pro-inflammatory (pēnei i te IL-1β, IL-12, TNFα, me te IFNγ) me te whakanui ake i ngā cytokine anti-inflammatory (pēnei i te IL-10). E kī ana ētahi kairangahau ko ngā momo hāora tauhohe (ROS) i hangaia e te HBOT ka whakahaere i ētahi pānga pai o te rongoā. Nō reira, i tua atu i tana mahi whakaiti mirumiru e whakawhirinaki ana ki te pēhanga me te whakatutukitanga o te nui o te hāora kiko, ko ngā putanga pai e pā ana ki te HBOT he mea whakawhirinaki ki ngā mahi ā-tinana o te ROS i hangaia.
2. Ngā Pānga o te HBOT ki te Apoptosis me te Neuroprotection
Kua whakaatuhia e ngā rangahau ka taea e te HBOT te whakaiti i te phosphorylation hippocampal o te p38 mitogen-activated protein kinase (MAPK), ā, ka whakapai ake i te hinengaro me te whakaiti i te kino o te hippocampal. Kua kitea ko te HBOT takitahi me te tangohanga Ginkgo biloba ka whakaiti i te whakaaturanga o Bax me te mahi o te caspase-9/3, ka hua ake he hekenga o ngā reiti apoptosis i roto i ngā tauira kiore i whakaohokia e te aβ25-35. I tua atu, i whakaatuhia e tētahi atu rangahau ko te whakaritenga HBOT i whakaoho i te manawanui ki te ischemia roro, me ngā tikanga e uru ana ki te whakanui ake i te whakaaturanga SIRT1, me te whakanui ake i ngā taumata lymphoma 2 pūtau-B (Bcl-2) me te whakaiti i te caspase-3 hohe, e whakaatu ana i ngā āhuatanga tiaki io me te ārai-apoptotic o te HBOT.
3. Te awe o te HBOT ki te Tohanga me teTe whanaketanga o te roro
Kua honoa te pānga o te HBOT ki te pūnaha toto o te angaanga, tae atu ki te whakarei ake i te urunga o te arai toto-roro, te whakatairanga i te angiogenesis, me te whakaiti i te pupuhi. Haunga te whakarato i te nui ake o te hāora ki ngā kiko, ko te HBOTka whakatairanga i te hanganga o ngā oko totomā te whakahohe i ngā take whakawhiti kōrero pēnei i te take tipu endothelial vascular me te whakaoho i te tipu o ngā pūtau take io.
4. Ngā Pānga Epigenetic o te HBOT
Kua whakaatuhia e ngā rangahau ko te pānga o te hāora hyperbaric ki ngā pūtau endothelial microvascular tangata (HMEC-1) ka whakahaere nui i ngā ira 8,101, tae atu ki ngā whakapuakanga kua piki ake me ngā whakapuakanga kua heke iho, e whakaatu ana i te pikinga o te whakapuakanga ira e pā ana ki ngā ara urupare antioxidant.
Whakamutunga
Kua tino piki haere te whakamahinga o te HBOT i roto i ngā wā, e whakaatu ana i tōna wātea, tōna pono, me tōna haumaru i roto i ngā mahi haumanu. Ahakoa kua tūhuratia te HBOT hei rongoā kore-tohu mō ngā NDD, ā, kua mahia ētahi rangahau, kei te hiahia tonuhia ngā rangahau pakari hei whakataurite i ngā mahi HBOT i roto i te rongoā i ēnei āhuatanga. He mea nui ngā rangahau anō hei whakatau i te auau maimoatanga tino pai me te aromatawai i te whānuitanga o ngā pānga pai mō ngā tūroro.
Hei whakarāpopototanga, ko te hononga o te hāora hyperbaric me ngā mate neurodegenerative e whakaatu ana i tētahi rohe whai hua mō ngā āheinga rongoā, e tika ana kia haere tonu te tūhuratanga me te whakamana i roto i ngā tautuhinga haumanu.
Wā tuku: Mei-16-2025