I roto i te ao rongoā hou, kua kitea ko ngā paturopi tētahi o ngā whanaketanga tino nui, e whakaiti ana i te maha o ngā mate me ngā mate e pā ana ki ngā mate huakita. Nā tō rātou kaha ki te whakarerekē i ngā putanga haumanu o ngā mate huakita kua roa ake te roanga o te oranga o te tini o ngā tūroro. He mea nui ngā paturopi i roto i ngā tikanga hauora uaua, tae atu ki ngā pokanga, ngā whakaurunga implant, ngā whakawhitinga wheua, me te chemotherapy. Heoi, ko te putanga mai o ngā pathogens ātete ki ngā paturopi he āwangawanga e tipu haere ana, e whakaiti ana i te whai huatanga o ēnei rongoā i roto i te wā. Kua tuhia ngā tauira o te ātete ki ngā paturopi puta noa i ngā momo paturopi katoa i te mea ka puta ngā whakarerekētanga huakita. Ko te pēhanga kōwhiringa e pā ana ki ngā rongoā paturopi kua whai wāhi ki te pikinga ake o ngā momo ātete, e waiho ana hei wero nui ki te hauora o te ao.
Hei whawhai i te take nui o te ātete ki ngā huakita, he mea nui kia whakatinanahia ngā kaupapa here whakahaere mate whai hua hei aukati i te horapa o ngā huakita ātete, me te whakaiti i te whakamahinga o ngā paturopi. Hei tāpiri, he hiahia nui mō ngā tikanga maimoatanga rerekē. Kua puta ake te Hyperbaric Oxygen Therapy (HBOT) hei tikanga whai hua i roto i tēnei horopaki, e uru ana ki te manawa o te 100% hāora i ngā taumata pēhanga motuhake mō tētahi wā. Ahakoa he maimoatanga tuatahi, he maimoatanga tāpiri rānei mō ngā mate, tera pea ka tukuna e te HBOT he tumanako hou ki te rongoā i ngā mate urutā i puta mai i ngā huakita ātete ki te paturopi.
Kei te piki haere te whakamahinga o tēnei rongoā hei maimoatanga tuatahi, hei maimoatanga rerekē rānei mō ngā momo āhuatanga, tae atu ki te mumura, te paihana hauota waro, ngā patunga mau tonu, ngā mate ischemic, me ngā mate pāwera. He hohonu ngā whakamahinga haumanu o te HBOT i roto i te maimoatanga mate pāwera, ā, he painga nui ki ngā tūroro.
Ngā Whakamahinga Hauora o te Whakaora Hāora Hyperbaric i roto i te Mate Pukupuku
E tautokona ana e ngā taunakitanga o nāianei te whakamahinga o te HBOT, hei maimoatanga takitahi, hei maimoatanga tāpiri hoki, ā, he nui ngā painga ki ngā tūroro kua pangia. I te wā o te HBOT, ka piki ake te pēhanga hāora toto uaua ki te 2000 mmHg, ā, ka taea e te pikinga pēhanga hāora-kiko teitei te whakanui ake i ngā taumata hāora kiko ki te 500 mmHg. He tino whai hua ēnei pānga ki te whakatairanga i te whakaora o ngā urupare mumura me ngā raruraru tohanga toto iti e kitea ana i roto i ngā taiao ischemic, tae atu ki te whakahaere i te mate wāhanga.
Ka pā anō hoki te HBOT ki ngā āhuatanga e whakawhirinaki ana ki te pūnaha ārai mate. E whakaatu ana ngā rangahau ka taea e te HBOT te pehi i ngā mate pūnaha ārai mate me ngā urupare ārai mate i puta mai i te antigen, ā, ka āwhina i te pupuri i te manawanui ki te whakawhiti mā te whakaiti i te rere o ngā lymphocytes me ngā leukocyte me te whakarerekē i ngā urupare ārai mate. Hei tāpiri, ko te HBOTtautoko i te whakaorai roto i ngā whara kiri mau tonu mā te whakaoho i te angiogenesis, he tukanga nui mō te whakaora pai ake. Ka akiakihia hoki e tēnei rongoā te hanganga o te matrix collagen, he wāhanga nui i roto i te whakaora patunga.
Me aro nui ki ētahi mate pāwera, inā koa ngā mate hōhonu me ngā mate uaua ki te rongoā pērā i te necrotizing fasciitis, te osteomyelitis, ngā mate kiko ngohengohe mau tonu, me te infectious endocarditis. Ko tētahi o ngā whakamahinga haumanu tino noa o te HBOT ko ngā mate kiri-kiko ngohengohe me te osteomyelitis e pā ana ki ngā taumata hāora iti e puta pinepine ana i ngā huakita anaerobic, ātete rānei.
1. Ngā Mate Waewae Mate Huka
Waewae mate hukaHe raruraru nui ngā mate pukupuku i waenga i ngā tūroro mate huka, ā, e pā ana ki te 25% o tēnei taupori. He maha ngā mate pukupuku e puta mai ana i roto i ēnei mate pukupuku (40%-80% o ngā take) ā, ka piki ake te mate me te mate. Ko ngā mate waewae mate huka (DFI) he maha ngā mate polymicrobial me ngā momo pathogens huakita anaerobic kua tautuhia. He maha ngā āhuatanga, tae atu ki ngā hapa mahi fibroblast, ngā raruraru hanganga collagen, ngā tikanga ārai pūtau, me te mahi phagocyte, ka ārai i te whakaora patunga i roto i ngā tūroro mate huka. He maha ngā rangahau kua tautuhia te ngoikore o te hāora kiri hei take mōrearea kaha mō ngā tapahi e pā ana ki ngā DFI.
Hei tētahi o ngā kōwhiringa o nāianei mō te maimoatanga DFI, kua pūrongohia he nui te tere o te whakaora a te HBOT mō ngā mate pukupuku waewae mate huka, ā, ka whakaitihia te hiahia mō ngā tapahi waewae me ngā pokanga uaua. Ehara i te mea ka whakaitihia noa te hiahia mō ngā tikanga e nui ana te rauemi, pērā i ngā pokanga flap me te grafting kiri, engari he iti ake ngā utu me ngā pānga taha iti iho i ngā kōwhiringa pokanga. I whakaatuhia e tētahi rangahau nā Chen et al. neke atu i te 10 ngā wā o te HBOT i arahi ki te 78.3% te whakapainga o ngā tere whakaora patunga i roto i ngā tūroro mate huka.
2. Ngā Mate Pukupuku Ngāwari e Whakamatea Ana i te Pūkahukahu
He maha ngā wā he maha ngā momo huaketo e puta mai ana i ngā mate pāwera kiko ngohengohe e puta mai ana i te necrotizing tissue (NSTI), ā, he maha ngā wā ka puta mai i te huinga o ngā pathogens huakita aerobic me anaerobic, ā, he maha ngā wā ka hono atu ki te whakaputa hau. Ahakoa he onge noa iho ngā NSTI, he nui te mate nā te tere o te whanaketanga. Ko te tātaritanga me te maimoatanga tika me te wā tika te mea nui ki te whakatutuki i ngā putanga pai, ā, kua tūtohutia te HBOT hei tikanga tāpiri mō te whakahaere i ngā NSTI. Ahakoa kei te noho tonu te tautohetohe mō te whakamahinga o te HBOT i roto i ngā NSTI nā te kore o ngā rangahau whakahaeretia,e whakaatu ana ngā taunakitanga he hononga pea tēnei ki te pikinga o ngā reiti oranga me te tiakitanga okana i roto i ngā tūroro NSTII whakaatuhia e tētahi rangahau whakamuri he whakahekenga nui o ngā reiti mate i waenga i ngā tūroro NSTI e whiwhi ana i te HBOT.
1.3 Ngā Mate Pāwera o te Wāhi Pokanga
Ka taea te whakarōpū i ngā SSI i runga i te wāhi tinana o te mate, ā, ka puta mai i ngā momo pathogens, tae atu ki ngā huakita aerobic me ngā huakita anaerobic. Ahakoa ngā whanaketanga o ngā mahi whakahaere mate, pērā i ngā tikanga whakahoromata, te whakamahinga o ngā paturopi ārai mate, me ngā whakapainga i roto i ngā mahi pokanga, he raruraru tonu ngā SSI.
Kua tirotirohia e tētahi arotake nui te whai huatanga o te HBOT ki te aukati i ngā SSI hōhonu i roto i te pokanga scoliosis neuromuscular. Tērā pea ka whakaitihia e te HBOT i mua i te pokanga te auau o ngā SSI me te āwhina i te whakaora patunga. Ka hangaia e tēnei rongoā kore-whakaeke he taiao e piki ake ai ngā taumata hāora i roto i ngā kiko patunga, e pā ana ki te mahi whakamate waikura ki ngā pathogens. Hei tāpiri, ka aro atu ki te whakahekenga o te toto me ngā taumata hāora e whai wāhi ana ki te whanaketanga o ngā SSI. Haunga ētahi atu rautaki whakahaere mate, kua tūtohutia te HBOT mō ngā pokanga poke-kore pērā i ngā tikanga colorectal.
1.4 Ngā tahunga
Ko ngā weranga he whara i puta mai i te wera nui, te hiko, ngā matū, te irahiko rānei, ā, ka nui ake te mate me te mate. He pai te HBOT mō te rongoā i ngā weranga mā te whakanui ake i ngā taumata hāora i roto i ngā kiko kua pakaru. Ahakoa he rerekē ngā hua o ngā rangahau kararehe me ngā rangahau haumanu mōte whai huatanga o te HBOT i roto i te maimoatanga wera, i roto i tētahi rangahau i uru atu ki te 125 o ngā tūroro wera, i whakaatuhia kāore he pānga nui o te HBOT ki ngā reiti mate, ki te maha rānei o ngā pokanga i mahia, engari i whakaitihia te wā whakaora toharite (19.7 ngā rā ki te 43.8 ngā rā). Mā te whakauru i te HBOT ki te whakahaere whānui i te wera ka taea te whakahaere pai i te sepsis i roto i ngā tūroro wera, ka poto ake te wā whakaora me te whakaiti i ngā hiahia wai. Heoi, me nui ake ngā rangahau tirohanga whakamua hei whakaū i te tūranga o te HBOT i roto i te whakahaere i ngā wera nui.
1.5 Te mate wheua o te wheua
Ko te Osteomyelitis he mate pāwera o te wheua, o te hinu wheua rānei, e hua pinepine ana i ngā mate kitakita. He uaua te rongoā i te osteomyelitis nā te ngoikore o te rere o te toto ki ngā wheua, me te iti o te urunga o ngā paturopi ki roto i te hinu wheua. Ko te osteomyelitis mau tonu e tohuhia ana e ngā mate pāwera tonu, te mumura ngawari, me te hanganga kiko wheua necrotic. Ko te osteomyelitis ātete e pā ana ki ngā mate wheua mau tonu, e hoki mai ana rānei ahakoa te maimoatanga tika.
Kua whakaatuhia te kaha o te HBOT ki te whakapai ake i ngā taumata hāora i roto i ngā kiko wheua kua pangia. He maha ngā raupapa take me ngā rangahau whakarōpū e whakaatu ana ka whakarei ake te HBOT i ngā putanga haumanu mō ngā tūroro osteomyelitis. Te āhua nei ka mahi mā roto i ngā tikanga maha, tae atu ki te whakanui ake i te mahi pākia, te pehi i ngā pathogens kitakita, te whakarei ake i ngā pānga paturopi, te whakaiti i te mumura, me te whakatairanga i te whakaora.ngā tukanga. I muri i te HBOT, 60% ki te 85% o ngā tūroro e pāngia ana e te osteomyelitis mau tonu, uaua ki te whakatika ka whakaatu i ngā tohu o te pehi i te mate.
1.6 Ngā Mate Harore
Neke atu i te toru miriona tāngata e pāngia ana e ngā mate harore mau tonu, e whakaeke ana rānei, ā, neke atu i te 600,000 ngā mate i ia tau. He maha ngā wā ka pāngia ngā hua maimoatanga mō ngā mate harore nā ngā āhuatanga pēnei i te whakarerekētanga o te tūnga ārai mate, ngā mate huna, me ngā āhuatanga kaha o ngā mate. Kei te piki haere te rongonui o te HBOT hei whiringa rongoā mō ngā mate harore kino nā te mea he haumaru, he kore whakaeke hoki. E whakaatu ana ngā rangahau he whai hua pea te HBOT ki ngā mate harore pēnei i te Aspergillus me te Mycobacterium tuberculosis.
Ka whakatairangahia e te HBOT ngā pānga harore mā te aukati i te hanganga biofilm o Aspergillus, me te pikinga o te whai huatanga i kitea i roto i ngā momo kāhore he ira superoxide dismutase (SOD). Ko ngā āhuatanga hypoxic i te wā o ngā mate harore he wero ki te tuku rongoā harore, ka waiho ko te pikinga o ngā taumata hāora mai i te HBOT he wawaotanga whai hua pea, ahakoa me rangahau anō.
Ngā Āhuatanga Paturopi o te HBOT
Ko te taiao paitini nui i hangaia e te HBOT ka tīmata i ngā huringa ā-tinana me ā-matū koiora e whakaoho ana i ngā āhuatanga patu huakita, ka waiho hei rongoā tāpiri whai hua mō te mate. Ka whakaatuhia e te HBOT ngā pānga whakamiharo ki ngā huakita aerobic me ngā huakita anaerobic te nuinga mā roto i ngā tikanga pēnei i te mahi patu huakita tika, te whakarei ake i ngā urupare ārai mate, me ngā pānga tahi me ngā kaihoko patu huakita motuhake.
2.1 Ngā Pānga Ārai Mate Huakita Tika o te HBOT
Ko te pānga tika o te HBOT ki te patu huakita e pā ana ki te whakaputanga o ngā momo hāora tauhohe (ROS), tae atu ki ngā anion superoxide, te hauwai peroxide, ngā radical hydroxyl, me ngā ion hydroxyl—e puta katoa ana i te wā o te pākia o te pūtau.
He mea nui te taunekeneke i waenga i te O₂ me ngā wāhanga pūtau hei mārama ki te āhua o te hanganga o te ROS i roto i ngā pūtau. I raro i ētahi āhuatanga e kiia nei ko te ahotea waikura, ka whakararuraruhia te taurite i waenga i te hanganga ROS me tōna pirau, ka hua ake he taumata teitei o te ROS i roto i ngā pūtau. Ka whakakorikoria te hanga o te superoxide (O₂⁻) e te superoxide dismutase, ka huri i te O₂⁻ hei hauwai waikura (H₂O₂). Ka whakanuia ake tēnei huringa e te tauhohenga Fenton, e waikura ana i te Fe²⁺ hei whakaputa i ngā rauropi hydroxyl (·OH) me te Fe³⁺, ā, ka tīmata he raupapatanga redox kino o te hanganga ROS me te kino o te pūtau.
Ko ngā pānga paitini o te ROS e aro ana ki ngā wāhanga pūtau nui pērā i te DNA, te RNA, ngā pūmua, me ngā lipid. He mea nui, ko te DNA te ūnga matua o te paitini pūtau e whakahaerehia ana e te H₂O₂, nā te mea ka whakararuraru i ngā hanganga deoxyribose me te kino i ngā hanganga turanga. Ko te kino ā-tinana i puta mai i te ROS ka horapa ki te hanganga helix o te DNA, tera pea ka puta mai i te peroxidation lipid i whakaohokia e te ROS. E whakaatu ana tēnei i ngā hua kino o ngā taumata ROS teitei i roto i ngā pūnaha koiora.
Te Mahi Ārai-pūmua o te ROS
He mea nui te mahi a te ROS ki te aukati i te tipu o ngā moroiti, e whakaaturia ana i roto i te whakaputanga ROS i puta mai i te HBOT. Ko ngā pānga paitini o te ROS e pā tika ana ki ngā wāhanga pūtau pēnei i te DNA, ngā pūmua, me ngā lipid. Ka taea e ngā kukū tiketike o ngā momo hāora hohe te kino tika i ngā lipid, ka arahi ki te peroxidation lipid. Ka whakararu tēnei tukanga i te pumau o ngā kiriuhi pūtau, ā, nō reira, te mahi a ngā kaiwhakawhiwhi me ngā pūmua e hono ana ki te kiriuhi.
Hei tāpiri atu ki tēnā, ko ngā pūmua, he whāinga ngota ngota nui hoki o te ROS, ka pāngia e ngā whakarerekētanga waikura motuhake i ngā toenga waikawa amino pērā i te cysteine, te methionine, te tyrosine, te phenylalanine, me te tryptophan. Hei tauira, kua whakaaturia te kaha o te HBOT ki te whakaputa i ngā huringa waikura i roto i ētahi pūmua i roto i te E. coli, tae atu ki te elongation factor G me te DnaK, ā, ka pā ki ā rātou mahi pūtau.
Te Whakapai Ake i te Ārai Mate mā te HBOT
Ngā āhuatanga ārai-mumura o te HBOTkua tuhia, he mea nui mō te whakaiti i te kino o te kiko me te pehi i te haere whakamua o te mate. He nui te pānga o te HBOT ki te whakaaturanga o ngā cytokine me ētahi atu kaiwhakahaere mumura, e awe ana i te urupare ārai mate. He maha ngā pūnaha whakamātautau i kite i ngā huringa rerekē o te whakaaturanga ira me te whakaputa pūmua i muri i te HBOT, e whakanui ana, e whakaiti ana rānei i ngā mea whakatipu me ngā cytokine.
I te wā o te tukanga HBOT, ka whakaohohia e te pikinga o ngā taumata O₂ te whānuitanga o ngā urupare pūtau, pērā i te pehi i te tukunga o ngā takawaenga mumura me te whakatairanga i te apoptosis lymphocyte me te neutrophil. I te katoa, ka whakarei ake ēnei mahi i ngā tikanga patu huakita o te pūnaha ārai mate, ā, ka āwhina i te whakaora i ngā mate.
Hei tāpiritanga, e whakaatu ana ngā rangahau ka taea e te pikinga o ngā taumata O₂ i te wā o te HBOT te whakaiti i te whakaaturanga o ngā cytokine pro-inflammatory, tae atu ki te interferon-gamma (IFN-γ), te interleukin-1 (IL-1), me te interleukin-6 (IL-6). Kei roto hoki i ēnei huringa te whakaheke i te ōwehenga o ngā pūtau T CD4:CD8 me te whakarerekē i ētahi atu kaiwhakawhiwhi wairewa, ā, i te mutunga ka piki ake ngā taumata interleukin-10 (IL-10), he mea nui hei ārai i te mumura me te whakatairanga i te whakaora.
E hono ana ngā mahi patu huakita o te HBOT ki ngā tikanga koiora matatini. Kua pūrongohia te kaha o te superoxide me te pēhanga teitei ki te whakatairanga i te mahi patu huakita i puta mai i te HBOT me te apoptosis neutrophil. Whai muri i te HBOT, ka whakanuia e te pikinga nui o ngā taumata hāora ngā kaha patu huakita o ngā neutrophil, he wāhanga nui o te urupare ārai mate. Hei tāpiri, ka pehia e te HBOT te piri o te neutrophil, e whakahaerehia ana e te taunekeneke o ngā β-integrins i runga i ngā neutrophils me ngā ngota piri intercellular (ICAM) i runga i ngā pūtau endothelial. Ka aukati te HBOT i te mahi a te neutrophil β-2 integrin (Mac-1, CD11b/CD18) mā te tukanga e whakahaerehia ana e te hauota hauota (NO), e whai wāhi ana ki te hekenga o ngā neutrophils ki te wāhi o te mate.
He mea tika te whakarerekētanga tika o te anga pūtau kia taea ai e ngā neutrophils te whakapūpū i ngā mate. Kua whakaatuhia te S-nitrosylation o te actin ki te whakaoho i te polymerization actin, ka taea te whakahaere i te mahi phagocytic o ngā neutrophils i muri i te maimoatanga i mua i te HBOT. Heoi anō, ka whakatairangahia e te HBOT te apoptosis i roto i ngā raina pūtau T tangata mā roto i ngā ara mitochondrial, me te tere o te mate lymphocyte i muri i te HBOT. Ko te aukati i te caspase-9—me te kore e pā ki te caspase-8—kua whakaatu i ngā pānga immunomodulatory o te HBOT.
Ngā Pānga Mahi Tahi o te HBOT me ngā Āpiha Paturopi
I roto i ngā mahi haumanu, he maha ngā wā ka whakamahia te HBOT me ngā paturopi hei whawhai i ngā mate. Ka pā te āhua hyperoxic i te wā o te HBOT ki te whai huatanga o ētahi kaihoko paturopi. E whakaatu ana ngā rangahau ko ngā rongoā patu huakita motuhake, pērā i ngā β-lactams, fluoroquinolones, me ngā aminoglycosides, ehara i te mea mā roto noa i ngā tikanga ā-roto engari ka whakawhirinaki hoki ki te pākia o te huakita. Nō reira, he mea nui te noho o te hāora me ngā āhuatanga pākia o ngā pathogens ina aromatawaihia ngā pānga rongoā o ngā paturopi.
Kua whakaatuhia e ngā taunakitanga nui ka taea e te iti o te hāora te whakanui ake i te ātete o Pseudomonas aeruginosa ki te piperacillin/tazobactam, ā, ka whai wāhi hoki te iti o te hāora ki te whakanui ake i te ātete o Enterobacter cloacae ki te azithromycin. I tetahi atu taha, ka taea e ētahi āhuatanga hypoxic te whakanui ake i te aro o te huakita ki ngā paturopi tetracycline. Ko te HBOT he tikanga rongoā tāpiri whai hua mā te whakaoho i te pākia o te tinana me te whakaora anō i ngā kiko kua pangia e te hypoxic, ā, ka whakanui ake i te aro o ngā pathogens ki ngā paturopi.
I roto i ngā rangahau haumanu-mua, ko te whakakotahitanga o te HBOT—i tukuna kia rua ngā wā i te rā mō ngā hāora 8 i te 280 kPa—me te tobramycin (20 mg/kg/rā) i tino whakaiti i te nui o ngā huakita i roto i te Staphylococcus aureus infectious endocarditis. E whakaatu ana tēnei i te kaha o te HBOT hei maimoatanga āwhina. Kua whakaatuhia e ngā rangahau anō i raro i te 37°C me te pēhanga 3 ATA mō ngā hāora 5, i tino whakanuia e te HBOT ngā pānga o te imipenem ki te Pseudomonas aeruginosa i pangia e te macrophage. I tua atu, i kitea ko te tikanga whakakotahi o te HBOT me te cephazolin he pai ake te rongoā i te Staphylococcus aureus osteomyelitis i roto i ngā tauira kararehe ki te whakataurite ki te cephazolin anake.
Ka whakanuia anō hoki e te HBOT te mahi patu huakita o te ciprofloxacin ki ngā kiriata koiora Pseudomonas aeruginosa, inā koa i muri i te 90 meneti o te pānga. E pā ana tēnei whakarei ake ki te hanganga o ngā momo hāora tauhohe taketake (ROS) ā, e whakaatu ana i te tairongo nui ake i roto i ngā mutants peroxidase-defective.
I roto i ngā tauira o te pleuritis i puta mai i te methicillin-resistant Staphylococcus aureus (MRSA), ko te pānga mahi tahi o te vancomycin, teicoplanin, me te linezolid me te HBOT i whakaatu i te pikinga nui o te whai huatanga ki te MRSA. Ko te Metronidazole, he paturopi e whakamahia whānuitia ana ki te rongoā i ngā mate kino anaerobic me te polymicrobial pērā i ngā mate waewae mate huka (DFIs) me ngā mate wāhi pokanga (SSIs), kua whakaatu i te whai huatanga antimicrobial teitei ake i raro i ngā āhuatanga anaerobic. Me whai rangahau ā muri ake nei ki te tūhura i ngā pānga antibacterial synergistic o te HBOT i honoa ki te metronidazole i roto i ngā tautuhinga in vivo me in vitro.
Te Whai Huatanga Ārai-Paturopi o te HBOT ki ngā Huakita Ātete
I te whanaketanga me te horapa o ngā momo ātete, ka ngaro te kaha o ngā paturopi tuku iho i roto i te wā. Hei tāpiri, tera pea ka kitea he mea nui te HBOT hei rongoā me te aukati i ngā mate i puta mai i ngā pathogens ātete-maha-rongoā, ā, he rautaki nui tēnei ina kore e angitu ngā maimoatanga paturopi. He maha ngā rangahau kua pūrongo i ngā pānga patu huakita nui o te HBOT ki ngā huakita ātete e tika ana ki te haumanu. Hei tauira, ko te wā HBOT 90-meneti i te 2 ATM i tino whakaiti i te tipu o te MRSA. Hei tāpiri, i roto i ngā tauira ōwehenga, kua whakarei ake te HBOT i ngā pānga patu huakita o ngā momo paturopi ki ngā mate MRSA. Kua whakaūhia e ngā pūrongo he whai hua te HBOT ki te rongoā i te osteomyelitis i puta mai i te Klebsiella pneumoniae e whakaputa ana i te OXA-48 me te kore e hiahiatia he paturopi tāpiri.
Hei whakarāpopototanga, ko te rongoā hāora hyperbaric he huarahi maha-āhuatanga ki te whakahaere mate, e whakarei ake ana i te urupare ārai mate me te whakanui ake i te whai huatanga o ngā rongoā paturopi o nāianei. Mā te rangahau me te whanaketanga whānui, kei a ia te kaha ki te whakaiti i ngā pānga o te ātete ki ngā paturopi, e tuku ana i te tumanako ki te pakanga tonu ki ngā mate huakita.
Te wā tuku: 28-Pepuere-2025